By Fayen Wong and Clare Baldwin
SHANGHAI/HONG KONG (Reuters) - Chinese authorities were slaughtering birds at a poultry market in the financial hub Shanghai as the death toll from a new strain of bird flu mounted to six on Friday, spreading concern overseas and sparking a sell-off on Hong Kong's share market.
State news agency Xinhua said the Huhuai market for live birds in Shanghai had been shut down and birds were being culled after authorities detected the H7N9 virus from samples of pigeons in the market.
All of the 14 reported infections from the H7N9 bird flu strain have been in eastern China and at least four of the dead are in Shanghai, a city of 23 million people and the showpiece of China's vibrant economy.
Xinhua did not say how many birds would be culled.
In Hong Kong, shares tumbled to a four-month low on Friday on worries that the new strain of bird flu could hurt the local economy.
"The bird flu issue is at the top of people's minds now," said Alfred Chan, chief dealer at Cheer Pearl Investment in Hong Kong.
Chinese airlines were among the biggest percentage losers on the day, including China Southern Airlines, China Eastern Airlines and Air China. Cathay Pacific also fell.
The strain does not appear to be transmitted from human to human but Hong Kong airport authorities said they were taking precautions. Vietnam banned imports of Chinese poultry.
In Japan, airports have put up posters at entry points warning all passengers from China to seek medical attention if they have flu-like symptoms.
In the United States, the White House said it was monitoring the situation and the Centers for Disease Control and Prevention (CDC) said it had started work on a vaccine if it was needed. It would take five to six months to begin commercial production.
With the fear that a SARS-like epidemic could re-emerge, China said it was pulling out the stops to combat the virus.
"(China) will strengthen its leadership in combating the virus ... and coordinate and deploy the entire nation's health system to combat the virus," the Health Ministry said in a statement on its website (www.moh.gov.cn).
SHADOW OF SARS
In 2003, authorities initially tried to cover up an epidemic of Severe Acute Respiratory Syndrome (SARS), which emerged in China and killed about 10 percent of the 8,000 people it infected worldwide.
China "will continue to openly and transparently maintain communication and information channels with the World Health Organization and relevant countries and regions, and strengthen monitoring and preventative measures", the ministry said.
Shanghai has suspended poultry sales at two other markets and ordered through disinfection of the premises. In Huhuai, authorities were conducting proper disposal of the culled birds, their excrement and contaminated food as well as disinfection of the market, Xinhua said.
The virus has been shared with World Health Organization (WHO) collaborating centers in Atlanta, Beijing, London, Melbourne and Tokyo, and these groups are analyzing samples to identify the best candidate to be used for the manufacture of vaccine - if it becomes necessary.
Any decision to mass-produce vaccines against H7N9 flu will not be taken lightly, since it will mean sacrificing production of seasonal shots.
That could mean shortages of vaccine against the normal seasonal flu which, while not serious for most people, still costs thousands of lives.
Sanofi Pasteur, the world's largest flu vaccine manufacturer, said it was in continuous contact with the WHO through the International Federation of Pharmaceutical Manufacturers and Associations (IFPMA), but it was too soon to know the significance of the Chinese cases.
Other leading flu vaccine makers include GlaxoSmithKline and Novartis
Preliminary test results suggest the new flu strain responds to treatment with Roche's drug Tamiflu and GSK's Relenza, according to the WHO.
Other strains of bird flu, such as H5N1, have been circulating for many years and can be transmitted from bird to bird, and bird to human, but not generally from human to human.
So far, this lack of human-to-human transmission also appears to be a feature of the H7N9 strain.
"The gene sequences confirm that this is an avian virus, and that it is a low pathogenic form (meaning it is likely to cause mild disease in birds)," said Wendy Barclay, a flu virologist at Britain's Imperial College London.
"But what the sequences also reveal is that there are some mammalian adapting mutations in some of the genes."
(Additional reporting by Ben Blanchard in BEIJING; Olivier Fabre in TOKYO, Hanoi newsroom; Kate Kelland in LONDON and Julie Steenhuysen in CHICAGO; Editing by Raju Gopalakrishnan)
Source: http://news.yahoo.com/more-deaths-china-bird-flu-u-japan-guard-021437256.html
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